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KMID : 0380620070390050564
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Korean Journal of Food Science and Technology
2007 Volume.39 No. 5 p.564 ~ p.568
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Antimicrobial Effect of Achyranthes japonica Nakai Extracts against Clostridium difficile
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Jung Sun-Mi
Choi Soo-Im
Park Sang-Min
Heo Tae-Ryeon
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Abstract
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In this study, the ethanolic extracts of 40 species of traditional herbal medicines were examined for their antimicrobial activities against Clostridium difficile. Among the 43 screened traditional herbal medicines, Achyranthes japonica Nakai (AJN), Siegesbeckia glabrescens Makino, and Phelloedendron amurense Ruprecht showed antimicrobial activities greater than 90% at a concentration of 500 ppm. According to the minimum inhibitory concentration (MIC) test, the ethyl acetate soluble fraction of the AJN ethanolic extracts (AJNEA) showed the highest growth inhibitory activity against C. difficile, with a MIC of 625 μg/mL. In addition, the effect of AJNEA on the growth of lactic acid bacteria was investigated. AJNEA did not inhibit the growth of the tested Bifidobacterium spp. or Lactobacillus spp., with the exception of B. longum, Streptococcus thermophilus, and L. helveticus. These results indicate that AJNEA can be utilized as a potential antimicrobial agent against C. difficile related disease.
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KEYWORD
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Achyranthes japonica Nakai, antimicrobial effect, Lactic acid bacteria, Clostridium difficile, minimum inhibitory concentration
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